The Constitution has a mechanism for conflict resolution. It is called the amendment process.
The reason the Constitution binds the states permanently to the Union is because of the failures of the Articles of Confederation.
"I do not conceive we can exist long as a nation, without having lodged somewhere a power which will pervade the whole Union in as energetic a manner, as the authority of the different state governments extends over the several states. To be fearful of vesting Congress, constituted as that body is, with ample authorities for national purposes, appears to me to be the very climax of popular absurdity and madness."
George Washington to John Jay, 15 August 1786
"What stronger evidence can be given of the want of energy in our government than these disorders? If there exists not a power to check them, what security has a man of life, liberty, or property? To you, I am sure I need not add aught on this subject, the consequences of a lax or inefficient government, are too obvious to be dwelt on. Thirteen sovereignties pulling against each other, and all tugging at the federal head, will soon bring ruin to the whole; whereas a liberal, and energetic Constitution, well guarded and closely watched, to prevent encroachments, might restore us to that degree of respectability and consequence, to which we had a fair claim, and the brightest prospect of attaining..."
George Washington to James Madison November 5, 1786
The states were bound to the Union because that was the only way to secure the blessings of liberty, ensure domestic tranquility, and the rest.
Look around.
It worked.
Walt
I agree with you 100% right down the the past tense of "It worked".
It no longer does!