I think Jim Robinson has as good an answer as anyone with the Free Republic mission statement.
The answer is to return the Federal government to its constitutionally mandated functions and let each State deal with domestic issues, in accordance with the Tenth Amendment.
Those States that pursue destructive policies will be seen for the failures they are, while those States that govern wisely will thrive and their ideas will spread.
I believe this would have a beneficial effect on the drug problem as well as other domestic problems.
Also it will (or already has) lead to complexities such as we have with gun laws. What is perfectly legal here in Tennessee will get you serious jail time in California or Maryland or Massachusetts. Remember the old oil company PR ads? "The is no simple solution, only intelligent responses" or something to that effect....