To answer your question, MissAmericanPie, there are many many references to the U.S.A. in biblical prophecy. Stewart Best wrote a long and very comprehensive six-part series of articles on the subject "Is America Babylon?" You can find the links to these articles on our FR home page.
Important prophecies re principles of prophecy:
Stanley Frodsham (1965) The Coming Deception
Revelation given to Nicolai re the Strait Gate
Vision of the Sword and the Serpent
Vision of the Acid Cloud - 1994
Important prophecies about America:
A.C. Valdez (1929)
A.A. Allen (1954)
Zelma Kirkpatrick (1954)
Henry Gruver (1986)
Dimitru Duduman
Henry Gruver, I saw Russians Attack the USA
Dream of the Capturing of Many Women - 1997 -- re Muslims
Scott Hofstee - Sept. 3, 2001 (prophesied people jumping to their death just before the towers fell)
Scott Hofstee in 2001
Last Trumpet - August 2001 (saw vision of NY island on fire before WTC fell)
Bob Neumann: The Dark Winter
Bob Neumann: The Alarm was Sounded
Jerry Golden: Vision of 10-06-01
Jonathan Hansen, known for his accuracy, said here that unless America repents, it will soon see 1,000 times the death toll of WTC, and ultimately millions. Go here for current and Archived Broadcasts.
David Wilkerson: "The Towers Have Fallen, but We Missed the Message" html - plain text- Real Audio- Windows streaming audio- If the Real Audio is busy
Stewart Best: Teaching (doesn't claim to be a prophet). This is the six part teaching series by Stewart Best. It discusses whether America is Mystery Babylon described in Jer. 50 & 51, Is. 13, Ezek. 38, Rev. 17 & 18 and other scriptures and if so the consequences. It is very complete. If you are short of time, start with Part 5: Part 1, - Part 2, - Part 3, - Part 4, - Part 5 (start here), - Part 6.
As bad as America is, it's still the most righteuos country on earth from God's perspective. (Notwithstanding our many serious sins, what current country on earth deserves God's blessing more?) So here's how I think (just speculating) that God will "destroy" the USA...
What if there was a huge evangelical revival in America and many millions of Americans sincerely turn to Christ. What if there ws a revolt against our secular, materialistic, media-driven society, and Americans by the tens of millions gave their lives to Jesus...then... The Rapture!
Imagine 70 or 80-million Americans suddenly gone, and only the godless left behind. It would "destroy" America. Europe would be relatively "untouched" by the rapture. So would Asia and Russia and the Middle East. But America would be most depleted by the Rapture, and those left behind would not exactly be our "best and brightest".
It's admittedly a rose-colored scenario (just a speculation on my part), but not out of the question, and not our of keeping with God's nature. For all of our abortion and love of money and media, we are still the most sincerely Christian nation on earth.