IMHO that is a key issue in determining wheather everything is working like it should according to the Constitution.
Historically, the common meaning of the term "regulate" as used in the 18th century was "to make regular", or "generally to keep in good working order". This is the only definition that makes the phrase "a well regulated militia" found in the Second Amendment sensical.
That meaning has been supplanted with the more recent definition, "to control or exercise authority over" with respect to Article 1 Section 8, and has been used to give Congress a virtual blank check under the Commerce Clause.
By way of analogy, imagine your community having a contractural agreement with the power company, stipulating that they are required to, and will be granted whatever authority they need to insure that the power is regulated - meaning kept within the prescribed limits of voltage and phasing so that everything works like it ought to. It does not mean that the power company can come into your home, and dictate what appliances you may or may not own, when you may use them, or what you may use them for.
There are several remedies for this, any time the people are so inclined.