[maro]

Assuming that's so, I don't see the relevance. It's the a priori probability we're interested in, no? Let's say that a thousand people try to break the bank at Monte Carlo, come hell or high water. With that assumption, the wealth states of these folks might plausibly be predicted to 1 or 0 eventually, where 1 represents the bank. That doesn't change the (daunting) a priori odds of breaking the bank at Monte Carlo.

[Nebullis]

It is relevant to a discussion of transitions between phenotypic expression. That may be a side issue to the main point of the thread, but it's important to show that what is irrelevant is the demand for smooth transitions based on single point mutations.