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Ritalin May Change Brain Long-Term, Study Shows
Reuters News Service ^ | November 11, 2000 | Reuters Staff

Posted on 11/12/2001 5:15:21 PM PST by t-shirt

Ritalin May Change Brain Long-Term, Study Shows

Sunday November 11 2001

WASHINGTON (Reuters) - The stimulant Ritalin (news - web sites), a drug used to help children with attention deficit hyperactivity disorder, may cause long-term changes in the brain, researchers reported Sunday.

The changes look similar to those seen with other stimulants such as amphetamine and cocaine, at least in rats, the team at the University of Buffalo found.

``Clinicians consider Ritalin to be short-acting,'' Joan Baizer, a professor of physiology and biophysics who led the study said in a statement.

``When the active dose has worked its way through the system, they consider it 'all gone.' Our research with gene expression in an animal model suggests that it has the potential for causing long-lasting changes in brain cell structure and function.''

But Baizer said that Ritalin, known generically as methylphenidate, probably is not addictive in the way drugs of abuse are if it is used properly.

``Children have been given Ritalin daily for many years, and it is extremely effective and beneficial, but it's not quite as simple as a short-acting drug,'' she said. ``We need to look at it more closely.''

High doses of amphetamine and cocaine have been found to switch on genes known as ``immediate early genes'' in brain cells. One of the genes, called c-fos, has been linked with addiction when it is activated in certain parts of the brain.

The researchers gave rat pups sweetened milk carrying methylphenidate in comparable doses and at similar times to what a child would get.

C-fos genes were activated in their brains in a pattern similar to that seen in cocaine and amphetamine use, the researchers told a meeting of the Society for Neuroscience in San Diego.

``These data do suggest that there are effects of Ritalin on cell function that outlast the short term and we should sort that out,'' Baizer said.

She said perhaps a gene chip -- a microarray -- could be used to see just which genes are turned on and off by methylphenidate.


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To: t-shirt
Can you try to act like a man instead of like a child misbehaving in a chatroom?

These people can't help it. They've taken too many psych drugs and fried their brains.

41 posted on 11/12/2001 7:16:51 PM PST by Bump in the night
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To: anniegetyourgun
I'll not bother you anymore.

You ARE the weakest link! Goodbye!!!!!

42 posted on 11/12/2001 7:17:48 PM PST by Bump in the night
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To: mlocher
or is it to make the lives of the public school teacher easier?

Bingo! It's all about control.

43 posted on 11/12/2001 7:18:45 PM PST by Bump in the night
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To: copycat
My son's school said they wanted to test my son for ADHD. I told them I thought it was junk science and refused to allow him to be tested. I told them kids had been growing fine for thousands of years before Ritalin came along.

Good for you!!!!!!!!!!!!!!!!!!!

44 posted on 11/12/2001 7:22:25 PM PST by Bump in the night
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To: Coleus
Corporal punishment never worked for my dad. He was beaten by the nuns, and still was hyper and got in trouble. Corporal punishment didn't work for my brother either. Even getting kicked out of school didn't work. Now he's an adult leading a pretty crappy life. ADHD in adults sucks. He can't keep a steady job, can't keep a steady relationship, and just when things look like they get going good, it's all downhill again.....tell ya, he could have used some Ritalyn when he was a kid. Now they're putting him on Effexor.
45 posted on 11/12/2001 7:22:42 PM PST by HelgaHawk
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To: Bump in the night
Did I mistakenly post something to you? If so, I apologize. I'll not bother again either.
46 posted on 11/12/2001 7:24:54 PM PST by anniegetyourgun
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To: copycat
If your school's advice was your first indication that your child might have a problem, then you are correct in your assessment. Parents of kids who need Ritalin usually know there's a problem well in advance of the school's discovery.

Whether or not Ritalin is the answer is another story.

47 posted on 11/12/2001 7:36:16 PM PST by edayna
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To: Coleus
Ritalin will always be around, it's the easy way out and convenient. Most ADHD is due to allergies, diet related, etc. Can be controlled but it takes TIME and WORK.

I'm in full agreement with this statement. I happen to know a kid who *needs* Ritalin in order to function like a normal human being. I've been well acquainted with the entire process of before and after. But serious allergies run in the family - she's got some - and she's a very picky eater. It's much easier to fine-tune her Ritalin dose than to figure out the underlying cause. In my opinion, unless she's been diagnosed with a Ritalin deficiency, there has to be another answer. It's not a dietary supplement, after all.

48 posted on 11/12/2001 7:43:31 PM PST by edayna
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To: edayna
My child suffered from "only child" syndrome, in other words, he was spoiled and not used to having to be disciplined (in the military sense.)

He didn't need drugs, he just needed to adjust.

The fact that the school sought to "cure" his inattentiveness with drugs should be distressing to all parents. That and the fact that I understand schools receive a "kickback" for each child they have on the stuff.

49 posted on 11/12/2001 7:44:44 PM PST by copycat
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To: t-shirt
Excellent article t-shirt and a very important one. don't let the nattering nabobs of negativism bother you, just ignore them next time.
50 posted on 11/12/2001 7:45:23 PM PST by Red Jones
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To: Bump in the night
You know... I'm begining to think that you work for Eli Lilly. You sure do jump on every single anti-psych drug thread that comes across Free Repubic and try to convince us that taking drugs is okay... as long as a quack... oops... I mean psych... gives them to you. I think that you get paid to do this.

No I do not. I endorse Ritalin use as a last resort not a first choice. I work for no one because I'm on disability. Why? Well it seems the ADHD they thought I had as a kid was instead sensory processing disorders. Very close in behavioral characteristics but thats where it stops. I took Ritalin about at age 7 or 1965 for less than a month. It didn't help me in fact it made me worse. So much for an endorsement huh?

What I have found out though is ADD ADHD in most cases is a common misdiagnoses of sensory processing disorders. I also understand that all it takes to trigger it is a Nitendo, cartoon, tv show, ghetto blaster, or strobe light. Mom and Pop rent or buy The Lion King an innocent enough cartoon for most kids. Except for those with C.A.P.D. The scene changes and screen flashes set off the ADHD type behavior. That is why this nation is in a Ritalin epidemic. The drugs didn't change BUT the triggering devices causing the symptoms that are misdiagnosed as ADD ADHD did. Simple enough? Medications? I recommend getting the root cause illness treated. For example. Ever hear the term "Snotty Nose Brat?" Yes and it's called that and for a good reason. Treat the sinus allergy to limit further sensory damage. Sinus allergies destroy over time the Inner Ear. Inner Ear dysfunction spells cognitive problems.

When I post in a Ritalin thread I post to limit it's usage and to educate others to a common missed problem because of the ADD ADHD misdiagnoses. Oh BTW if left untreated these disorders can lead to what is called Generalized Anxiety Disorders where everything seen and heard is misinterpited as dangers and the fight or flight survival response is triggered. Then you start using medications far more frequently.

51 posted on 11/12/2001 7:50:20 PM PST by cva66snipe
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To: Al B.
What a pile of cr@p. There is no scientific basis for that statement. If you've got one, name it.

He doesn't have to. It's the military's decision, not his. They're simply using the existence of a Ritalin prescription in a recruit as an indication that the guy's probably going to have a lot of trouble being a good soldier because of his ADD or whatever, so they 4F him and send him on his way. Just like if they saw a list of heavy chemotherapy drugs on his chart, they'd say, "Jeez, this kid's got cancer!" and never let him enlist until he was in remission.

52 posted on 11/12/2001 7:59:29 PM PST by Timesink
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To: cva66snipe
Okay... I get where you're coming from now. Good response!I would just go so far as to say that ADHD is (overall) a crock of sh*t. That's interesting what you've said about ADHD being caused by sensory processing disorders. I don't know anything at all about that one... but what you say makes a lot of sense. I know for a fact that MANY times "Hyperactivity" can be totally handled by simply handling a kids diet. Sugar and red dye will make a kid act hyper. Some kids are allergic to wheat, so wheat will make them act hyper. I just don't think that drugging kids is ever the answer. I think it simply hides the problem, rather than handling it. When a kid is acting hyper, we need to find out the REAL reason... the EXACT reason WHY the kid is being hyper... and handle it. Not give them drugs which simply masks the problem. Thanks for the data though!
53 posted on 11/12/2001 8:01:42 PM PST by Bump in the night
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To: cva66snipe
You can change the subject all you want. The issue is and has been the general usage of Ritalin for psychiatric disorders like ADHD. There is no scientific basis to support these disorders as brain malfunctions and there isn't one credible psychopharmacologist, NIMH researcher, or APA flack that will publicly state otherwise.

As you and I have discussed before, there are certainly medical reasons behind a limited number of childhood psychiatric problems. These should be treated as medical problems, NOT psychiatric ones. And there is certainly no excuse to drug millions of kids with this stuff.

54 posted on 11/12/2001 8:03:45 PM PST by Al B.
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To: Al B.
And there is certainly no excuse to drug millions of kids with this stuff.

And for those that missed that... It's worth repeating...
"And there is certainly no excuse to drug millions of kids with this stuff."

55 posted on 11/12/2001 8:06:56 PM PST by Bump in the night
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To: Timesink
He doesn't have to. It's the military's decision, not his. They're simply using the existence of a Ritalin prescription in a recruit as an indication that the guy's probably going to have a lot of trouble being a good soldier because of his ADD or whatever, so they 4F him and send him on his way. Just like if they saw a list of heavy chemotherapy drugs on his chart, they'd say, "Jeez, this kid's got cancer!" and never let him enlist until he was in remission.

I went on active duty in 1976 and got out in 1980. I went on disability in 1994. During my 4 years active duty the condition that caused my ADHD symptoms acted up. I was removed from "The Hole" or "Boiler Room" on a medical necessity. I was going deaf and staggering around. I wore my hearing protection so that wasn't the issue. The 100% humidity was though to my Inner Ear and allergies. The Chief Engineer wanted a Boiler Tech he ended up with a Machinist Mate working in Air Conditioning & Refrigeration instead. I could have never worked in The Hole. But In was recommended for re-enlistment. I got out instead. I would not have seen my 20 years active had I stayed in. Though at that time I didn't realize the cause or extent of my problem.

56 posted on 11/12/2001 8:12:07 PM PST by cva66snipe
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To: Bump in the night
That's interesting what you've said about ADHD being caused by sensory processing disorders

Sensory Processing disorders are mistaken for ADD ADHD in most cases. While they can co-exist with each other in some cases the C.A.P.D. is the most common between them. It's serious enough that in my state kids are tested for C.A.P.D. They made the amazing discovery that most of their supposed ADD ADHD's kids were indeed not. Like I said the problems came with the newer technologies started triggering sensory processing disorder kids. The technology of 1965 was giving me trouble as a kid. It isn't hard for me to understand the effects todays technology has on them as it effects me severly as an adult. It doesn't go away.

57 posted on 11/12/2001 8:21:43 PM PST by cva66snipe
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To: Timesink
He doesn't have to. It's the military's decision, not his.

I was referring to a statement he made about Ritalin usage for underlying neurological problems, not any statements about military policy.

My understanding of DOD policy comes from a Cox News Service article in 1996 which states:

"A longstanding Department of Defense directive also instructs the military to reject those with a 'chronic history' of an academic skills defect -- including ADD -- after age 12. And people who took Ritalin as teenagers to treat ADD, an inhibitor of academic skills, are rejected from military service, even if they no longer take the medication."

58 posted on 11/12/2001 8:24:07 PM PST by Al B.
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To: t-shirt
FReep Halibut Award-- Dishonorable Mention
59 posted on 11/12/2001 8:25:20 PM PST by let freedom sing
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To: cva66snipe
Two questions:
What is C.A.P.D.?
What do they do to treat sensory processing disorder in kids?
60 posted on 11/12/2001 8:25:43 PM PST by Bump in the night
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