Posted on 09/03/2025 10:45:10 AM PDT by bitt
Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections A Phase 2 Randomized Clinical Trial
It may be OTC in Germany but it does not appear to be so here.
There’s an otc version in the US as well. Not as potent as the script version
Search for “Astepro Allergy”. Looks OTC.
It is sold here as “Astepro”, among other names.
Check the ingredient list.
One of the reasons we are trillions in the hole with our deficit.
I have used it for a couple years. It marginally seems to help my allergies.
Where are the $hot $hill$ ??
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Peter McCullough is big advocate for nasal mists. However, he does it on the cheap with a diluted povidone-iodine and distilled water mixture. It has to be significantly diluted to avoid nasal burning of the delicate nasal membrane. I use it before I go out in the public. I have a small glass bottle I can carry in my pocket with a nasal pump/mister cap
When I got full blown Covid-19, I took Benadryl, and it worked. Kept it out of my lungs and stopped the drainage. Got rid of the dry cough.
But why take an antihistamine when you can take diamine oxidase enzyme and get rid of histamines in your body rather than just block the histamine receptor.
There are 4 types of histamine receptors throughout the body. They are in the brain, sinuses, lungs, stomach, heart, and the mast cells all over the body.
I’m pretty sure that the heart damage caused by Covid-19 was due to the histamine receptors in the AV node of the heart. The AV node is the heart’s pacemaker and when the histamine receptors in it are stimulated it causes a premature firing through the Purkinje fibers without sufficient charge for a full ventricle contraction to pump the blood.
My heart arrhythmia stopped when I took the diamine oxidase enzyme and my energy returned.
Walgreens has it and it has a coupon
so, how many people are going to spray this stuff in each nostril three times a day for the rest of their lives?
Small sample. I wouldn’t expect that GP has ever heard of MOE, much less understand how to apply it.
I believe Bangladesh did a push for nasal sprays during COVID and had great outcomes for the populations prior to getting the vaccines.
Azelastine is a second-generation H1 histamine receptor antagonist that works by blocking the effects of histamine and other inflammatory substances in the body. It is commonly used as a nasal spray or eye drops to treat allergy symptoms.
Mechanism of action
Azelastine’s effectiveness is due to a multi-pronged approach that targets different aspects of the allergic response:
H1-receptor blocker: It is a selective antagonist of the H1 histamine receptor, meaning it competes with histamine to prevent it from binding to these receptors.
This action provides rapid relief from itching, sneezing, and runny nose.
Mast cell stabilizer: It prevents mast cells from releasing inflammatory mediators like histamine, which helps to inhibit the allergic reaction at an early phase.
Anti-inflammatory effects: Azelastine also blocks the action of other allergy-related substances, such as leukotrienes and cytokines, which contributes to its overall anti-inflammatory effects.
Histamine and cytokines interact in an important bidirectional network, with histamine influencing cytokine production and release in allergic inflammation and other immune responses.
Histamine, released by cells like mast cells, can promote Th2 cytokines (like IL-4 and IL-5) and inhibit Th1 cytokines (like IFN-γ), shifting immune responses toward allergic conditions.
Conversely, some cytokines can modulate histamine production, further illustrating the complex interplay between these molecules in various physiological and pathological processes, including allergic diseases and potentially cytokine storms in viral infections.
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