The cruel truth is that any Constitutional means of replacing Dementia Joe requires an honest government, and we don’t have one.
It’s important to remember that the body of the Constitution was written before the advent of political parties. It was naively believed that we would not repeat the mistake the Founders felt the English had made in their political system. The election of 1800 proved the Founders wrong.
The 25th Amendment was crafted for the situation we find ourselves in, but the mechanics of it require the VP and the President’s Cabinet to more or less betray either the well-being of the nation or the ‘leader’ of their party. The only way it will be invoked if Biden is in a long -term coma.