Yes they can!
I used to fix and calibrate the stuff!
If actuated a C5 can take off, fly somewhere, and land with someone just twisting dials.
In reality pilots are only needed for random events.
Oooo, “I used to fix and calibrated stuff”. There is no such thing as “auto-takeoff” on a manned aircraft - and “twisting dials”? what is that? I haven’t “twisted dials” on an aircraft since I flew DC-9s in the early 1980s. You’ve outed yourself as a know-nothing.
Every flight is filled with hundreds of what you call “random events.” No manned aircraft can “fly itself”. Even to suggest it reveals a total lack of knowledge of aviation.
I’ve flown airliners for 40 years. I’ve carried hundreds of thousands of passengers in my career as an international captain for a major US airline. Onboard fires, engine failures, severe turbulence, wind shear, medical emergencies, manual approaches to less than 1/2 mile visibility... I’ve got decades of stories how NOT EVEN ONE flight could “take off, fly somewhere, and land with someone just twisting dials.”
Go back to Microsoft Flight Simulator.