DWF mixed anxiety meds with her wine, then altitude was set to 9000 feet. A lot less oxygen. Reasonably sober and coherent at sea level can go to bat poop crazy at cruise altitude. Cabin pressures are typically set from 8000 feet to 10,000 feet.
Good point: hadn’t thought about the effects of altitude. The other thing is that female alcohol abusers are more likely than men to fly into rages when drunk.