Well, we did stupid things structurally to the Constitution, for example
1. 17th Amendment - Removed the state governments from having a direct corporate say in Federal policy. The senator devolved to nothing more than into another congresscritter. Now more personal career oriented than state needs oriented.
2. Reynolds vs Sims - paved the way for urban centers to dominate and financially exhaust states.
3. Wickard v. Filburn - Which allowed federal regulatory power into almost aspects of state commercial life.
There are some others I could name. These are IMO the most egregious examples.
“In a majority opinion joined by five other justices, Chief Justice Earl Warren ruled that the Fourteenth Amendment’s Equal Protection Clause requires states to establish state legislative electoral districts roughly equal in population. Warren held that “legislators represent people, not trees or acres. Legislators are elected by voters, not farms or cities or economic interests.” In his dissenting opinion, Associate Justice John Marshall Harlan II argued that the Equal Protection Clause was not designed to apply to voting rights.”
https://en.wikipedia.org/wiki/Reynolds_v._Sims
There was an 1872 case supporting Justice Harlan I believe.