The significance is the destiny of the immortal soul of Nancy Pelosi, and the souls of the several hundred million (or perhaps a billion) people around the world whose lives, physical bodies, faith, and deeds will be affected in one way or another by what Mrs. Pelosi does or professes in public concerning abortion.
The other interesting point is that each of us--including non-famous people--influence multitudes of other people for good or ill, depending on what we do or say. Mrs. P, through her office, influences a whole lot of them.
Now do Joe Biden.