[linMcHlp]

Endothelial expression of MHC class II molecules in autoimmune disease
https://pubmed.ncbi.nlm.nih.gov/14754393/

Excerpt from the abstract:

Increased endothelial MHC class II expression has been demonstrated in several autoimmune diseases, including myocarditis with dilated cardiomyopathy, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).

Recent data suggest that there is an association between endothelial expression of MHC class II molecules and diffuse endothelial dysfunction, which may be part of the explanation of the increased risk of cardiovascular disease in patients with RA, SLE and other chronic inflammatory conditions.

MHC class II transcription is in part genetically determined. Cytokine induced up-regulation of MHC class II molecules can be inhibited in vitro by antioxidants and different drugs, such as cyclosporin and statins.

Research on the development of new treatments for systemic autoimmune diseases and cardiovascular disease should include evaluation of effects on endothelial activation, including MHC class II expression.

This review also discusses the genetic basis of MHC class II expression and its implications for understanding MHC genotype associations with autoimmune diseases.

[jonrick46]

Not once have I seen any discussion of the Coxsackievirus, a significant cause of myocarditis and dilated cardiomyopathy (DCM). Instead of people having hand, foot, and mouth disease, they have contracted eye blinder disease.