Not a question of whether or not it will work. Desantis is in firm agreement with President Trump’s policies. If President Trump runs there is no reason for Desantis to run or join the ticket as he is far more effective as the Governor of Florida than he would be as a mere VP. Which is pretty much a ceremonial position with no real power.
He has far more influence as the Governor of Florida. And, he is still young, presidential-wise. He has plenty of time. And as a governor, he has the opportunity to further bolster his credentials for a future presidential run.
Glenn Beck called DeSantis “Trump without Twitter.” He can be very Trumpian when he wants to.