I don't see how Joe Biden can interfere with interstate commerce, he is the President but he does not have the power to shut it down. President Trump didn't shut it down in the first place, he had to ask the Governors to do it.
i think we are in a post-legal environment. do you trust scotus to uphold lower courts overturning such a rule, given sufficiently alarming noise about whatever the current variant is?
what they can do, of course, is go after air travel.