Yes, both J&J and AstraZeneca are adenovirus-based. I believe J&J uses a human adenovirus, while AstraZeneca uses a chimpanzee adenovirus. Otherwise the technology appears to be very similar. My opinion, is that that mRNA vaccines (i.e. Moderna and Pfizer) seem somewhat preferable to the adenovirus-based vaccines because they are bit less invasive. I say “less invasive” because the adenovirus-based vaccines use the adenovirus to get DNA into the cell nucleus which then produces mRNA which is used by the rhibosome floating about in the cytoplasm to produce the SARS-CoV-2 spike protein, while the mRNA vaccines don’t need to go into the cell nucleus as they are transporting mRNA for the SARS-CoV-2 spike protein through the cell wall into the cytoplasm.
That’s exactly my understanding too.
Well some questions come to mind:
1. Are the blood clot necessarily caused by the Adenovirus type vaccines?
2. Do we observe any similar blood clotting issues in mRNA vaccines?
If not, what other serious side effects have been observed in the mRNA vaccines?