I read it but I don’t understand it. My reading makes me think it is saying is that we might be training the bod to overreact when they get the virus. So a mutation to the SARS-Cov-2 might invoke a over reaction by the immune system of the vaccinated?
Am I reading that correctly or have 180 degrees backwards ?
There’s nothing specific to the vaccine in that article. What it’s saying is that there’s a risk of autoimmunity when your immune system develops a response to a protein which is similar to one already in your body. That risk is actually greater with the disease than it is with the vaccine since the vaccine can potentially target proteins dissimilar enough to native proteins that such a response doesn’t happen.
However, when presented with the whole virus, your immune system will trigger off any number of points once identifying the virus as foreign. If the dendritic cells happen to take proteins back to the lymph nodes which are similar enough to those present in your body normally, there’s a risk of autoimmune response. This really comes down to the dendritic cells and what samples are available to them. With the complete virus, it’s a crap shoot. Generation 3 (mRNA platform) vaccines have the opportunity to target proteins not found in the body. We just have to find ones that provoke an immune response, but lack any autoimmune issues.
That’s right.
Here’s an article about the paper.
https://www.sciencedirect.com/science/article/pii/S2589909020300186