Guys like Jack Dorsey aren't drug addicts. Their drug is ambition and power and it's a far better high than cocaine and heroin.
He's unkempt. He has a scraggly beard and shaggy hair. He appears to spend a lot of time outdoors. Not surprising as he's known to often take sabbaticals to far-Eastern religious meditative excursions. Otherwise, he looks like a typical Bay Area tech mogul.