There is a reason that the Mississippi River has been in approximately the same place for about 60 million years. Major fault system.
I thought these maps were interesting. https://duckduckgo.com/?q=new+madrid+fault+predictions+map&t=newext&atb=v233-1&iax=images&ia=images&iai=http%3A%2F%2F1.bp.blogspot.com%2F-ZWHdmDbubYM%2FUSo2i2tlz9I%2FAAAAAAAALgA%2F8tIscTvBYB0%2Fs400%2Fusa-map-navyd.jpg&pn=1