They key section regarding COVID-19 is...
5.8. Respiratory Viral Infection and COVID-19So we have another paper that indicates that supplementation with D3 is a smart thing to fight COVID. Dr. Seheult himself takes a daily regiment of Vitamin C, Vitamin D3, Quercitin and Zinc and he is on the front lines dealing with COVID-19 patients.
It is known that the outbreak of influenza infection is periodic and usually occurs during the wintertime at higher latitudes but is sporadic throughout the year in the tropical area. One of the proposed explanations is that the seasonal outbreak could be due to a seasonal variation in circulating levels of 25(OH)D which reaches the lowest levels in the winter. Several studies have supported this hypothesis as they reported the independent association between low level of serum 25(OH)D and incidence and severity of respiratory tract infection in children and adults. A prospective cohort study in healthy adults living in New England showed a two-fold reduction in the risk of developing acute respiratory tract infection (ARI) in those with serum 25(OH)D levels of 38 ng/mL (95 nmol/L) or more. A case-control study in children aged less than 2 years reported that children requiring hospitalization for ARI had significantly 1.7-times higher odds of vitamin D deficiency as compared to those with mild ARI. This indicates the protective effects of sufficient vitamin D status against respiratory viral infection. Respiratory viruses enter the respiratory epithelium via the specific entry receptors where it causes cellular and tissue damages and triggers innate and adaptive immune responses, which then result in airway and systemic inflammation and, in severe cases, life-threatening sepsis or acute respiratory distress syndrome. 1,25(OH)2D (the biologically active form of vitamin D is 1,25-dihydroxyvitamin D or 1,25(OH)2D) exerts anti-viral activities and modulates inflammatory response to viral infection by stimulating cathelicidin release, modulation of toll-like receptor expression and NK (Natural Killer) cells function, as well as suppressing over-expression of proinflammatory cytokines. A recent meta-analysis of 25 RCTs showed that supplementation of vitamin D2 or D3 can protect against the development of acute respiratory tract infection compared with placebo (odds ratio 0.88; 95% CI: 0.81–0.96).
The rise of the COVID-19 pandemic, the out-of-proportion rate of symptomatic infection, morbidity and mortality observed in African American and obese individuals suggests the possible impact of vitamin D on host response and susceptibility to the infection as obese and Black individuals are known to have an elevated risk for vitamin D deficiency. Apart from the immunomodulatory and anti-viral effects, 1,25(OH)2D acts specifically as a modulator of the renin–angiotensin pathway and down-regulates the expression of angiotensin converting enzyme-2 expression, which serves as the host cell receptor that mediates infection by SARS-CoV-2. It is therefore proposed that supplementation of vitamin D can reduce the risk and severity of COVID-19 infection.
Although the efficacy of vitamin D is still unclear as the results of ongoing clinical trials are still pending, it is advisable that one should maintain adequate vitamin D intake to achieve the desirable serum 25(OH)D level of 40–60 ng/mL (100–150 nmol/L) in order to minimize the risk and severity of COVID-19 infection. It is well documented that worldwide on average approximately 40% of children and adults have circulating levels of 25(OH)D <20 ng/mL (50 nmol/L) and approximately 60% <30 ng/mL (75 nmol/L). Thus, patients presenting to the hospital with COVID-19 are likely to have vitamin D deficiency or insufficiency. It is therefore reasonable to institute as a standard of care to give at least one single dose of 50,000 of vitamin D to all COVID-19 patients as soon as possible after being hospitalized. For patients who are intubated and are being fed by a G-tube, they should be treated with a liquid form of vitamin D. Drisdol is a pediatric liquid vitamin D2 formulation that contains 8000 IUs per mL that can be given daily to these patients to treat vitamin D deficiency.
I just ordered more D3 because I have a feeling we may see a shortage in the near future.
I have been using this period to catch up on my reading outside where I stock up on Vitamin D.
Please, just tell me how much D3 take, and how much is too much.
Good find!!!
This video is great. Thank you! :)