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To: avital2

was reading some stuff about the danger of using Propofol on covid patients. did some checking:

12 May: CNN: There’s a shortage of sedative for patients on ventilators due to Covid-19 pandemic, FDA says
From CNN Health’s Elizabeth Cohen
“The virus that causes Covid-19 has led to an increased number of people with severe respiratory illness. As a result, there is a shortage of FDA-approved drugs such as propofol that are used for sedation of mechanically ventilated patients,” according to a statement on the FDA’s website posted Monday.

Propofol is perhaps best known as the sedative that pop star Michael Jackson’s doctor administered to him as a sleeping aid.
In that statement, the agency issued an emergency use authorization for a sedative called Fresenius Propoven 2% emulsion, noting that it contains double the concentration of propofol compared to propofol products approved in the United States.
The FDA statement notes that Propoven “has not undergone the same type of review as an FDA approved product” and that pregnant women and children under 16 should not use it.
https://edition.cnn.com/us/live-news/us-coronavirus-update-05-12-20/h_77614bb29f328c7e2b3d499e24e13282

12 May: American Hospital Association: FDA authorizes propofol emulsion for emergency use for COVID-19 ventilator sedation
The Food and Drug Administration May 8 authorized (LINK) the emergency use of Fresenius Propoven 2% Emulsion, which the agency says “may be effective to maintain sedation via continuous infusion in patients greater than 16 years old with suspected or confirmed COVID-19 who require mechanical ventilation in an ICU setting.” The EUA was necessary because Fresenius Propoven 2% Emulsion has important differences in its formulation compared to FDA-approved propofol drugs; FDA therefore says that providers should consult the fact sheet (LINK) for more information before the drug’s administration...
https://www.aha.org/news/headline/2020-05-12-fda-authorizes-propofol-emulsion-emergency-use-covid-19-ventilator


17 posted on 07/07/2020 7:32:44 PM PDT by MAGAthon (h)
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To: MAGAthon
18 Jun: NCBI: The authors’ response: Propofol and sedation in patients with coronavirus disease 2019 Authors: Mitsuhito Soh, Toru Hifumi,⁎ Shutaro Isokawa, Masato Shimizu, Norio Otani, and Shinichi Ishimatsu Authors pointed out the risk of using propofol in patients with coronavirus disease 2019 (COVID-19) because it increased the activity and protein level of angiotensin-converting enzyme 2 (ACE2), which is known to play an important role in SARS-CoV-2 cell entry and transmission. Moreover, authors proposed that the use of propofol in patients with COVID-19 should be avoided, when possible, in favor of alternative sedative agents, including midazolam and dexmedetomidine... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299850/
18 posted on 07/07/2020 7:33:15 PM PDT by MAGAthon (h)
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