Hydroxychloroquine Study Corrected After More Than 100 Scientists Question Findings; Still Fails To Address Nine Other Points Raised By Reviewers

Epoch Times ^ | 05/31/2020 | BY KATABELLA ROBERTS

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Medical journal The Lancet on May 29 issued a correction to a recent study which found that antimalarial drugs Hydroxychloroquine and chloroquine were linked with an increased risk of mortality in hospitals, and an increased frequency of irregular heart rhythms.

The study, titled, “Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis,” and published on May 22, included records of 96,032 patients from 671 hospitals in six continents. The patients were hospitalized between Dec. 20, 2019, and April 14, 2020.

Patients receiving the anti-malarials were put in four different groups: chloroquine alone, chloroquine with a macrolide, hydroxychloroquine alone, or hydroxychloroquine with a macrolide. Patients who received none of the treatments formed a control group. Researchers found the 14,888 patients in the treatment group suffered higher mortality when compared to the control group of over 80,000.

“We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19,” the researchers wrote.

The study led the World Health Organization to temporarily suspend the trial of hydroxychloroquine on COVID-19 patients, and to the UK regulatory body, MHRA, requesting the temporary pause of recruitment into all hydroxychloroquine trials in the UK. France also changed its national recommendation of the drug in COVID-19 treatments and halted all trials.

However, more than a hundred scientists and medical professionals raised questions about integrity of data analyzed in the study and subsequently wrote an open letter to its authors and the editor of The Lancet, listing 10 major concerns.

These included the fact that there was “no ethics review,” and “unusually small reported variances in baseline variables, interventions and outcomes,” as well as “no mention of the countries or hospitals that contributed to the data source

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THE DAMAGE HAS BEEN DONE. WHO HAS STOPPED ALL STUDY OF HYDROXYCHLOROQUINE FOR COVID-19.

DESPITE THE CORRECTIONS, ALL OTHER ISSUES OF CONCERN WERE NOT ADDRESSED.

“The appendix has also been corrected. An incorrect appendix table S3 was included, originally derived from a propensity score matched and weighted table developed during a preliminary analysis. The unadjusted raw summary data are now included.”

The Lancet added that there “have been no changes to the findings of the paper,” and that the corrections have been made to the online version and will also be made to the printed version.

In response to the correction issued on May 29, James Watson, a Thailand-based statistician with the University of Oxford’s Centre for Tropical Medicine and Global Health, who led the drafting of the letter, told BuzzFeed News that the authors of the study had failed to address the other nine points referred to in the letter.

[Ouchthatonehurt]

not quite peer reviewed I’d say.

[SeekAndFind]

RE: not quite peer reviewed I’d say.

If so, why was it approved for publication at the LANCET and the study used as a basis for W.H.O policy and for other countries as well?

[SunkenCiv]

http://www.freerepublic.com/focus/search?m=all;o=time;q=quick;s=lancet

http://www.freerepublic.com/tag/lancet/index?tab=articles

[Ouchthatonehurt]

Peer review is dependent on the peers who review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420798/

My favorite is Alan Sokal though...hilarious:
https://www.washingtonpost.com/opinions/the-hilarious-hoax-that-should-have-taught-the-academy-a-lesson/2017/01/11/ffbbe1fe-d758-11e6-b8b2-cb5164beba6b_story.html

[tired&retired]

I remember reading that Dr’s at the Brigham & Women’s Hospital in Boston, that is affiliated with Harvard, have been working with the CIA for years, especially on special medical interrogation techniques.

I wouldn’t put it past the CIA to fund a project like this.

[Bayard]

This will all. Be debunked by the time the countries have moved on from their obsession with the 2020 US election cycle.

Just you wait, corrections will be made, but by that time they will be touting the benefits of a new vaccine that is better for the virus than hydroxychloroquine is.