While it’s not the US, there are some stats from Portugal, which decriminalized all drugs.
https://www.zerohedge.com/health/then-now-portugals-drug-decriminalization
Zerohedge is a junk site:
Recreational arijuana is decriminalized, but still illegal in Portugal. Medical marijuana was legalized only in 2018.
The explosion in AIDS cases occurred AFTER a 1987 program to give free, clean needles and condoms away.
Although they declined again, the murder rate in Portugal increased more than 50% after decriminalization, although this included many, more powerful drugs.
Addiction centers, established chiefly in the 1980s and 1990s, have seen a 60% increase rate in addictions since legalization (2001).
HIV infections among drug users declined 17% since decriminalization (2001), but 90% overall.
Drug use has increased more than 55% since 2001.
Portugal doesn’t prove drug decriminalization is a bad idea, but the evidence claimed by ZeroHedge is fake news; the real news is far from unambigious.