The fentanyl overdose epidemic has one cause: the government crackdown on legal, pure, pharmaceutical grade opioids. Drug laws did not exist until 1906 and most of the Founding Fathers were users. The federal government had no legal basis to ban any drug without a constitutional amendment until the New Deal Supreme Court decision Wickard v Filburn (1942) usurped the power to regulate everything. Drugs are a natural and originalist constitutional right, not a crime.
As a Christian, I oppose intoxication; however, I will concede that truly natural drugs are less dangerous than some of these artificial ones.
Having said that:
1. You did not prove that “most” of the Founding Fathers were “users”: Define what constituted a user, and who did what.
2. You fail to note the enormous profit incentive in synthetically producing artificial (not natural), and therefore patentable, drugs. That is how Big Pharma got BIG!