I’d write Flake off...he’s voting “NO” regardless of what the FBI does. To the ladies I would say, “I’d appreciate your vote in the affirmative, but if you don’t I’ll do my damnedest to make sure you get zero support for anything you ever want-to include reelection”.
Murkowski doesn’t care. She’s a progressive and apparently BFF with Feinswine. Collins is from a deep blue state and will do whatever she wants. They literally don’t care about the GOP agenda. The time to get them in line was long ago. But the Senate GOP would never elect a strong Majority Leader. They like it this way.
After Murkowski was able to win without conservatives and without support of the GOP itself - not to mention not even being on the ballot - she went much further left. She knows she can win if she has to without the GOP behind her. That’s what is bad about having such a thin majority that is dependent on having Senators like her as a part of it.