Manchin in WVa wouldn’t dare throw any hope of re-election away by opposing Trump’s pick. There are other Rat senators too. Trump has leverage to spare.
Yes, my guess is that some Dem Senators, who are up for re-election in red states (Manchin, Heitkamp, Tester, etc), will help create a quorum to facilitate a vote, but then will vote against the nominee. In other words, they will try to have it both ways. It still will expose them to their homestate voters as being captured by the Dem Leftist extremists and Chuck Schumer. This is great. It could help dump a couple of those redstate Dem Senators.