If you are going to be dodging bullets, the caliber makes little difference at all. Better to get in all your dodging BEFORE the trigger is pulled.
Despite popular mythology to the contrary, NOBODY outruns the shot.
A .22LR slug, lodged in the right place in the human body, and probably has not exited, can maim, severely disable or even kill the target. A .45 merely makes a bigger hole, and usually the exit hole is larger than the entrance wound.