Would your position be the same if these were gun confiscation laws? The 10th Amendment should be defended as strongly as the 2nd, IMO.
There is a difference between laws that fall outside the scope of enumerated federal powers and laws that directly contradict the Bill of Rights. Both are wrong, but one is much more wrong than the other. With at least a plausible “Commerce Clause” case for drug laws and no case at all for gun restrictions, I think my position is reasonable.