Why? The equation itself doesn't change. The math is still the same.
Plus I addressed the other galaxies. As below:
No matter how low the probability that any given galaxy will have intelligent life, the galaxy that we are in must have at least one intelligent species by definition (us). There could be hundreds of galaxies in our galactic cluster with no intelligent life whatsoever (or each with hundreds of species), but of course we would not be present in those galaxies to observe this fact.
Oh sure. A Vorlonian metrionic enigmal conumdrum. Throwing me a position that cannot be debated. Thanks a lot.
Of course I can answer with a hypothetical calculated probability, of the number of possible remote highly-advanced alien civilizations.
In the words of the late great Carl Sagan:
Billions and billions and billions.