Every chambering can be converted by the user with a caliber exchange kit. The 9×19mm Parabellum, .40 S&W, and .357 SIG chamberings share their polymer grip frame modules and this offers the possibility to interchange these three chamberings by swapping the top end — consisting of the slide, recoil spring assembly, barrel and the box magazine. Due to the significantly larger external dimensions of the .45 ACP cartridge compared to the other P320 chambering options, the .45 ACP chambering uses slightly wider .45 ACP specific polymer grip modules with an enlarged magazine well.
Unfortunately, the .45 version is NOT interchangeable with the other chamberings....