Ennui, or apathy, or nihilism is what happens to some men when the Spirit of the Lord departs and another spirit comes in. When God gives someone over, He gives them over to lesser elohim, fallen evil ones with the power to unhinge minds and cosmically inflate pride and other passions. 1 Sam. 16:14-23 KJV
People’s souls can incline so as to invite them, or reject them, in the face of the spirit of God.
I believe there is such a thing as an “eternal inclination” which makes such paradoxes as infallible predestination and genuine choice possible to coexist. The broad picture is painted on another plane, the eternal plane. In the plane of time, we have some leeway about details, yet never so as to surprise or get ahead of God.