How long has the space station been up??? Do you think that just perhaps, science has learned how to handle most of the problems you postulate??? In multiple ways??
I'm not saying the problems are unsolvable, but it's not really clear how they're going to be solved without a radical jump in technology to maybe, for example, supply the power necessary to create an electromagnetic field around the spacecraft that performs the same function as our planet's. Or develop a water and food recycling system that will sustain the crew. Drinking and eating what used to be urine and feces, without Earth's gradual recycling through soil and sun that allows us to not have to think about it, is something the astronauts might have to learn to stomach. Bottom line, getting the astronauts there is one thing. Getting them there and back alive is something else.
It's a lot easier when you are only 250 miles from Earth.