None at all. Eons ago, I saw one in Jeff Cooper's G&A page where the bad guy (some sort of major league doper) took 18 rounds of .357 Mag in the chest before deciding he didn't want to fight any more. DOA at the hospital, IIRC.
As for wanting a bigger caliber ... when the bad guy got up the second time, I think I'd be wanting a .600 Nitro Express ...