Ted Cruz has referred to the CFR as a “pernicious nest of snakes” and a “pit of vipers” in the past. I do not suppose Cruz thinks his wife is either of those. I am guessing it was just Mr. GOPe insider trying to make himself appear to be an outsider.
http://www.politico.com/blogs/ben-smith/2011/10/a-pit-of-vipers-also-his-wife-040327