What dog breed can stand up to a pack of 150lb wolves.
There are several breeds of working, shepherding dogs that can and will kill wolves.
Caucasian Mountain Dog.
Great Pyrenees Dog
Kangal Dog
Sarplaninac Dog
If you are talking about a wolf pack against a single dog, the dog loses, if you are talking one on one or pack against pack the dogs are just as good as the wolves.
A male Irish Wolfhound stands at least 32 inches tall at the shoulder and weighs at least 120 pounds. The Irish Wolfhound female is at least 30 inches tall and 105 pounds. Many are larger. Males usually average 34 to 35 inches and 140 to 180 pounds; females 32 to 34 inches and 115 to 140 pounds.
The biggest problem with these guys is that they think they're lapdogs! They can also be quite stubborn, but are still the sweetest, most even tempered things you can imagine.