Definitely.
And if your pack (or whatever you are lugging) does not fit well or starts to rub your skin or compress your spine, the situation while being forced to travel on foot can almost be hellish.
In many human disasters, you see the roads strewn with luggage, clothes, etc.
In one of the best planned bug outs of all time, the westward migration, the trailsides were often littered with abandoned furniture and other items. People will lighten their packs and abandon gear they decide isn't worth carrying, or they will cache it if they plan on coming back.