It’s a long, long ways and Iran is a very, very large country. Sites are spread out all over the place.
Never, never underestimate the abilities of Israel and her citizens.
Seemingly miraculous things will happen when the time arises.
Or an asymmetric strike may happen in a way that looks innocent at first. Say a few percent of the workers at an Iranian facility develop a disease which is fatal after a month or two. How many of the rest will go back to work?
Well, they won’t be striking the other 2/3 of Iran with F-15I and F-16I. Not without refueling way, way out.
It’s simply too far.
Cruise missiles from subs - yes, that will work in some cases.