I've read up on this a bit to see if things have really changed. We're talking about one facility in a mountain, a model I thought I had thought Iran had chucked a long time ago. If they simply go for distributed processing (lots of mountains), that 'MOP' strategy goes away because we will lack sufficient intelligence with which to manage sufficient targets over time, particularly with all the international blowback there will be after the first strike. We may then slow it, but not stop it. So at this point, that part of the war is a matter of how much money Iran can amass to 'mass produce' nuclear production facilities. Fortunately for them, the US and Turkey appear to be coming to their aid by taking the Kurds out of their path to the Mediterranean. Bizzarro.
Your suggestion about the leadership is more to the point but has its own blowback. Once we start a "take off the head" strategy with nations, that game is on against us too (not that it isn't to a degree already). Such would probably be a good thing temporarily, in that we might be better off without DC for a while with our government distributed all over the country, but it is in some respects easier to keep tabs on our enemies with them all in one place. Representation might get better if the people know where their representatives live and have them within easy reach. Heck, they could even build a "Senator's mansion," complete with a tree or lamp-post in front by way of suggestion. :-)
Leviathan become goo. Sigh.
However, with Iran, they are not civilized and the usual rationale doesn't really apply anymore because the Iranians would be dismantled from a pol-mil perspective and be placed in a situation where internal turmoil (power struggles) would ensue and internal deaths, assassinations, imprisonments, etc. . .those would stop them in their tracks for a long time as they try and establish another regime.
Unlike the civilized world where if decapitation takes place the chain of command would reach down however far it needs to (and takes some time), the Iranians have no such organization and a food-fight would surely begin and last until “they” establish their own, new power structure.
Any air strikes of any kind rely on accurate Intel, and I wager that if we ran MOP missions and a few select strike missions against leadership, we would see a lot of defections and others coming forward with Intel.
Besides, who do you think is building those complexes? We have Intel feeds from those countries that have the blue-prints and we can know how they are built and where their weak points are. . .and heck, we know where their entrances are and we can easily use MOP to drop the cave, close the entrances, basically shut them down without totally destroying the entire complex. . .stopping the program by suffocating the workers, technicians and scientists by burying them for decades under the rubble of a cave entrance, rubble that can extend down and out for a very long distance.
Just my thoughts.