Get out to where?
Well, yeah, there are excellent reasons secession is even less of a practical option than in 1860.
Then the seceding states were almost entirely united on the issue over which they seceded, although divided on whether secession itself was the way to address the issue. Once the fighting started, dissent in the south almost disappeared.
Today even the reddest states have very large minorities of people who disagree utterly on whatever issues secession might be over. And they are generally concentrated in the cities and especially the capitals.
So how does secession work when 30%, 40% or more of your population is violently opposed? Do you somehow figure out who is opposed and expel them, a type of ideological cleansing? If you do, how does that possibly jibe with the American ideals which you are theoretically fighting for?
Secession as a cure is very much like the equally silly notion of amendments or a constitutional convention as cures. If we can’t win elections, we certainly can’t successfully secede or pass amendments.