This could put big pressure on the GOP to have a woman and/or minority on the ticket. If Hillary gets the nomination, and especially if she picks a minority such as Castro HUD Secretary as her running mate, the GOP will be lambasted if there are two white men on the GOP ticket.
Unfair as it is, Ted Cruz is not considered Latino by the liberals or the media. Which means someone such as Governor Susana Martinez of New Mexico, or Governor Nikki Haley of South Carolina, would be strong choices as running mates for whoever wins the GOP pres. nomination.
Whomever is chosen as VP had better be a solid conservative - they'll be next in line. Bush was Reagan's biggest mistake.