A modern destroyer is still no match for modern air power.
Depends on the destroyer. A Burke class vessel would be extremely tough to take out unless you had a squadron or two of aircraft that had a ton of stand off anti-ship missiles and ARMs. Aircraft with iron bombs or short range missiles won't survive long enough to use them. Not many squadrons in that part of the world have that capability, which is good for us. However, since this is an Iranian ship, your statement stands and it would go to the bottom of the sea in short order.