Duke is #2 in offense points and Wisconsin is #10 in defensive points (fewest points against). So most the most skilled match-up will be Duke offense against Wisconsin defense.
Total net points per game favors Duke so Duke looks like the favorite to me.
Wisconsin has beat the Big Boys so who knows, destiny may be on their side.
Papa, that stat might be a bit misleading. Wisconsin's style doesn't lead to a lot of blow outs. How they played against Kentucky is how a number of their games have gone.