I doubt they’d be able to change their sex, I think organ rejection would be like x1000 with this
Have organs ever been successfully transplanted from male to female?
I have never heard of blood being segregated by sex (and yet there would be hormones present).
The brain would have to “learn” the processing/processes perhaps. But the article says that communicating with the new body itself would require relearning (as stroke patients and limb transplant patients must do).