I’m not sure simply “reasserting the 10th Amendment” by states is even possible, given the number of federal and Supreme Court decisions tying states to federal policies/laws. And there is the fact that states are literally addicted to federal money that provides funding for a number of programs - Medicaid/SNAP/Welfare/Education programs, just to name a few (throw in law enforcement as well).
It’s a process, granted, and it isn’t one that will be reversed overnight in any event.
“there is the fact that states are literally addicted to federal money”
THis is the major factor. It won’t be easy, that for sure, but I think it’s easier to assert Constitutional powers you already have rather than attempt to repeal an existing amendment.