I think there will be sections of the United States that attempt to secede. I doubt it will happen easily, because the areas that would like to leave have stuff like oil and agriculture and low debt that the rest covet.
Alaska might have a shot, geographically remote, maybe become a Russian protectorate.
Secession is not practical. I doubt there is a state in the country where a minimum of 1/3 of the population wouldn’t be “on the other side.”
Compare that to the CSA, which had 90%+ support in its core areas.
America’s divisions, this time around, just aren’t regional, they’re ideological. Which makes for a MUCH nastier civil war.
Ask the Spanish.