Iroquois legend has it the the Canadian Iroquois went south & wiped out a southern tribe who invaded NY State around 708 B.C years before Columbus, because the southern Tribe killed an emissary, a prince who came to them for peace terms..
I’ve read how the Iroquois left the New York area, went on a war raid and attacked a band of Pawnees on the High plains, all because the Pawnees had insulted or whipped some tribe friendly to the Iroquois.