Yes.
That’s what happens when they’re retreating, and bunched up.
Low tech armies have been using pickup-truck “technicals” in Africa since the 1980s ... they’re quite effective if used intelligently and in large numbers. Don’t under-estimate them.
In a battle of Technicals vs USA/USAF/USN/USMC ... I’m betting on US. But don’t think they can’t hurt us ... they can put a lot of bullets, SA-7s, and RPGs in our direction before we smash them all.