The Andy Warhol museum would go nicely in that building. The homosexual commercial artist moved to NYC early in his career but that may be a fundraising plus.
I don’t know if Warhol could fill that building, the space they have currently is much smaller I believe, and frankly you can tell they struggle to fill it with anything meaningful... I have no doubt the could just put more crap up to fill the space, but I don’t think it would make it any more relevant.