Yes; as soon as I booted up the computer, there it was. So of course it won’t let get to Start, another window, etc.
A freeper on this thread explained how he got out of it in a comment, it had to do with restarting his computer in safe mode.
I had a problem on my last computer with the flash player plug in to IE browser.
It caused Norton to issue a ‘Norton intercepted and deleted a dangerous Trojan virus file’ alert popup every time I went to a new address with IE. Even my home page triggered it.
It was very frustrating and took a while for me to figure out what was causing it. I did the safe mode reboot for that.