To be fair, Ryan did not get beat on content in that debate. He only ran into trouble because of his lack of experience on political debates at that level and dealing with the hardline leftist style of debating. So it is hard to count that too much against him.
But yes, this is gonna be a serious problem for him unless he can figure out how a solution that will involve actual conservatives achieving the goals they started out with in this fight.
Then he was a naive fool (including his coaching staff) for not anticipating or being able to handle Biden's smirks & guffawing & interruptions & bullying tactics. It's not like they hadn't seen the past 30 years of bluster & buffoonery from Biden and they were completely unprepared & naive to handle it.
Ryan looked like a deer frozen in the headlights, even the moderator would interrupt Ryan with no comeback from Ryan, and through it all Ryan just stood there frozen with a sick looking expression on his face. Perception is everything, points are nothing, when scoring a presidential or VP debate. And for this part, the GOP candidates usually are miserable in at least 2 out of 3 debates. Or in Ryan's case, he was miserable in 1 out of 1 debates.